How is your Methylation? What is it, whats wrong with your Folate (Folic acid) intake and why hasn’t the FDA/ TGA approved L-Methylfolate?

By Bryan Stralow, Editor-in-Chief,

These questions are rarely asked. Everyone “methylates”. Sounds ominous but I assure it is normal. We, being the collective human ‘cellular’ we, actually methylate at conception, or rather, fertilisation. Methylating as a zygote…  well, aren’t we clever!

As there are a multitude of natural, organic processes where methylation occurs, it tends to generally be a “transferral” process that can be categorised into two types: chemical and biological and is typically associated with the conversion of hydrogen.

Here’s what good old Wiki says today on Methylation:

In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group. Methylation is a form of alkylation, with a methyl group, rather than a larger carbon chain, replacing a hydrogen atom. These terms are commonly used in chemistry, biochemistry, soil science, and the biological sciences.

In biological systems, methylation is catalyzed by enzymes; such methylation can be involved in modification of heavy metals, regulation of gene expression, regulation of protein function, and RNA processing. In vitro methylation of tissue samples is also one method for reducing certain histological staining artifacts. The counterpart of methylation is called demethylation.

In laymen terms, it is the mechanical process in which our bodies are formed through heritable gene transfer, alkylation and so forth.

Why is this such a new and exciting topic? It has something to do with Big Pharma creating another high interest topic called ‘Epigenetics‘.


Epigenetics started its road to what is now quite prolific use in the 1990’s. It is, when the term is used correctly, the study of inherent or “heritable” genetic transfer. The mere etymology of the word indicates the meaning as “around genetics”, or “on top” or “outside of”.

Here is what Wiki says today on Epigenetics;

Epigenetic mechanisms
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.[1] The Greek prefix epi- (ἐπι- “over, outside of, around”) in epigenetics implies features that are “on top of” or “in addition to” the traditional genetic basis for inheritance.[2] Epigenetics most often denotes changes in a chromosome that affect gene activity and expression, but can also be used to describe any heritable phenotypic change that does not derive from a modification of the genome, such as prions. Such effects on cellular and physiological phenotypic traits may result from external or environmental factors, or be part of normal developmental program. The standard definition of epigenetics requires these alterations to be heritable,[3][4] either in the progeny of cells or of organisms.
The term also refers to the changes themselves: functionally relevant changes to the genome that do not involve a change in the nucleotide sequence. Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence. Gene expression can be controlled through the action of repressor proteins that attach to silencer regions of the DNA. These epigenetic changes may last through cell divisions for the duration of the cell’s life, and may also last for multiple generations even though they do not involve changes in the underlying DNA sequence of the organism;[5] instead, non-genetic factors cause the organism’s genes to behave (or “express themselves”) differently.[6]
One example of an epigenetic change in eukaryotic biology is the process of cellular differentiation. During morphogenesis, totipotent stem cells become the various pluripotent cell lines of the embryo, which in turn become fully differentiated cells. In other words, as a single fertilized egg cell – the zygote – continues to divide, the resulting daughter cells change into all the different cell types in an organism, including neurons, muscle cells, epithelium, endothelium of blood vessels, etc., by activating some genes while inhibiting the expression of others.[7]
Historically, some phenomena not necessarily heritable have also been described as epigenetic. For example, the term epigenetic has been used to describe any modification of chromosomal regions, especially histone modifications, whether or not these changes are heritable or associated with a phenotype. The consensus definition now requires a trait to be heritable for it to be considered epigenetic.[4] Misuse of the scientific term by quack authors has created misinformation and controversy in the public.[8]

Sex determination, what colour your hair is and so forth is all caused by Epigenetic processes in which methylation plays an important role. Converting heavy metals like arsenic, cadmium and mercury, and other organic compounds into various forms that assist and determine health and genetics. Well they don’t always assist despite the humdrum especially in the case of heavy metals, i.e. conversion of Cadmium into Dimethylcadmium, aka the most dangerous chemical in the world


One of the latest in a long string of what we call “complex supplements” is L-Methylfolate, also known as Levomefolic Acid. It is predominately being marketed to assist in the uptake and efficacy of Antidepressants also being used, strangely enough, to treat different types of cancer.

The following is an excerpt from the write up on the projected growth within the Antidepressant industry over the next five years:

Global Antidepressant Drugs Market 2018-2023
February 26, 2018 08:08 ET | Source: Research and Markets
Dublin, Feb. 26, 2018 (GLOBE NEWSWIRE) — The “Global Antidepressant Drugs Market – Analysis By Drugs Class, By Sales Channel, By Region, By Country: Opportunities and Forecasts (2018-2023)” report has been added to’s offering.

The global antidepressants market is projected to display a robust growth represented by a CAGR of 3.12 % during 2018 – 2023.

The segment of Selective Serotonin Reuptake Inhibitors (SSRIs) drug class witnessed growth at a noteworthy rate over the past few years and in the forecast period on the back of rising awareness related metal disorders, rising healthcare expenditures along with rising disposable incomes.

Amongst the regions, North America accounts for the largest regional share in the global antidepressant drugs market in 2017. Key factors driving the robust growth rate of North America region include rising healthcare expenditure, addition of new drugs, rising disposable incomes, rising number of hospitals and clinics etc.

The report intends to provide cutting-edge market intelligence and help decision makers take sound investment evaluation. Besides, the report also identifies and analyses the emerging trends along with major drivers, challenges and opportunities in the global antidepressants drug. Additionally, the report also highlights market entry strategies for various companies across the globe.

Scope of the Report

Global Antidepressants Market, By Value (Actual Period: 2013-2017, Forecast Period: 2018-2023)

Antidepressant Drugs Market – Sizing and Growth
Analysis By Drugs Class – Tricyclic Antidepressants, Selective Serotonin Reuptake Inhibitors, Selective -Norepinephrine Reuptake Inhibitors, Monoamine Oxidase Inhibitors, Benzodiazepines, Antipsychotics, Novel Agents
Analysis By Sales Channels – Hospital & Clinics, Retail Pharmacies, Others
Country Analysis – U.S., Canada, Germany, United Kingdom, India, Japan China, Brazil, Saudi Arabia (Actual Period: 2013-2017, Forecast Period: 2018-2023)

Antidepressant Drugs Market – Sizing and Growth
Analysis By Drugs Class – Tricyclic Antidepressants, Selective Serotonin Reuptake Inhibitors, Selective -Norepinephrine Reuptake Inhibitors, Monoamine Oxidase Inhibitors, Benzodiazepines, Antipsychotics, Novel Agents
Other Report Highlights

Market Dynamics – Drivers and Restraints
Market Trends
Porter Five Force Analysis
Policy and Regulatory Landscape
Company Analysis – Pfizer, GlaxoSmithKline, Allergan, Forest laboratories, Takeda, Novartis, Eli Lilly
Key Topics Covered:

1. Research Methodology

2. Executive Summary

3. Strategic Recommendations

4. Antidepressant Drugs Market Outlook

5. Global Antidepressant Drugs Market: Growth and Forecast

6. Global Antidepressant Drugs Market: By Drugs Class

7. Global Antidepressant Drugs Market: By Sales Channels

8. Global Antidepressant Drugs Market: Pipeline Analysis

9. Global Antidepressant Drugs Market: Regional Analysis

10. Market Dynamics

11. Market Trends

12. Policy and Regulatory Landscape

13. Porter’s Five Forces Analysis – Antidepressant Drugs Market

14. SWOT Analysis – Antidepressant Drugs Market

15. Company Profiles
Forest laboratories
Eli Lilly
For more information about this report visit



L-Methylfolates and the alcohols that carry these substances often slow or stop Methylation because they inhibit folic acid absorption in the stomach, reduce B vitamins, elevate homocysteine, cause folate deficiencies, can inhibit expression of the reduced folate carrier and decrease the hepatic uptake and renal conservation of circulating folate. In other words, these products have a high chance of stopping methylation which is important for DNA replication and mitochondrial function.

Now for the bad news, if you are eating food grown with cadmium-rich fertilisation, which is a very large portion of the population, combining with L-methylfolate supplements which are available everywhere, you are running the distinct and elevated chance of converting the cadmium in your food, which is already bad enough, to, that’s right, Dimethylcadmium and then you ‘won’t be in Texas anymore…’ 

You will be pushing up daisies and adding to the cadmium levels in our soil and agriculture. Take a closer look by typing cadmium into the search here on and you will see why people should be more aware of the types of food we eat, how it is grown and what types of supplements are on the market.

The FDA, in the US, and the TGA in Australia and New Zealand need to do their jobs and stop playing up to the Pharma’s who aren’t even required to test marketed  supplements which are so readily available.

Featured image courtesy of Pixabay